These parts of the selectin molecules are responsible for their targeting to different compartments: P-selectin to secretory granules, E-selectin to the plasma membrane, and L-selectin to the tips …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on vascular surfaces, the first adhesive step during inflammation and immune surveillance. …

Aug 2, 2025 · P-selectin is found on both platelets and endothelial cells, becoming rapidly available on the cell surface upon activation. These distinct cellular locations reflect their …

L-selectin, which is found on leukocytes, was the first discovered, by virtue of an interesting phenomenon called lymphocyte homing, in which lymphocytes were removed from various …

Jul 19, 2023 · Three type-I-cell surface glycoproteins make up the selectin family, namely L-selectin, P-selectin and E-selectin.

Apr 20, 2025 · The selectin family consists of three main types: E-selectin (expressed on endothelial cells), P-selectin (found on platelets and endothelial cells), and L-selectin (present …

Three selectins (P-selectin, E-selectin, and L-selectin) have been identified, each differing in their patterns of expression and regulation.

The human L-selectin gene (sell) is located on the long arm of chromosome 1 (1q24.2), and is arranged in tandem with its family members (in the order: L-, P-, and E-selectin).

Nov 30, 2023 · Members of the selectin family, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet), all of which bind to fucosylated carbohydrates [1]. For example P-selectin …

This review summarizes selectin biology and pathology, structure and ligand binding, and selectin antagonists that have reached clinical testing with an emphasis on E-selectin.