Protein post-translational modifications (PTMs) increase the functional diversity of the proteome by the covalent addition of functional groups or proteins, proteolytic cleavage of regulatory subunits, or …

Post-translational modification of proteins can be experimentally detected by a variety of techniques, including mass spectrometry, Eastern blotting, and Western blotting.

May 8, 2024 · Here, we summarize five key examples of post-translational modifications. This is not an exhaustive list, as over 200 different types of post-translational modifications have been identified …

PTMs encompass a wide variety of chemical modifications, including phosphorylation, acetylation, ubiquitination, glycosylation, and methylation. Each modification has different structural and …

Explore post-translational modifications (PTMs)—their diverse types, critical cellular functions, and real-world examples. Learn how PTMs shape protein activity, influence health, and play a role in disease …

Jul 30, 2025 · Post-translational modification of proteins can affect function, stability and expression. Do you know the various PTMs your protein can undergo? Check out our A-Z guide.

Jul 19, 2023 · One example is the activation of p53, a tumor suppressor protein. p53 is used in cancer therapeutics and is activated by phosphorylation of its N-terminal by several kinases.

Master Post-Translational Modification with free video lessons, step-by-step explanations, practice problems, examples, and FAQs. Learn from expert tutors and get exam-ready!

Jul 24, 2025 · Post-translational modifications are carried out by specialized cellular machinery in specific compartments. Many modifications, including glycosylation and disulfide bond formation, …

Below are some of the most representative PTM types, their mechanisms, and their roles in research and clinical applications: 1. Phosphorylation is the most extensively studied PTM.