The Role of GITR/GITRL Interaction in Autoimmune Diseases
Oct 9, 2020 · Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some …
TNFRSF18 - Wikipedia
GITR is co-stimulatory surface receptor for T cells and after interaction with GITRL maintain T cell activation, proliferation, cytokine production, and rescue T cells from anti-CD3-induced apoptosis.
GITRL enhances cytotoxicity and persistence of CAR-T cells in ...
Jun 4, 2025 · Here, we demonstrated that the overexpression of GITR ligand enhances the anti-tumor activity of CAR-T cells.
GITR/GITRL: More than an effector T cell co-stimulatory system
Apr 19, 2007 · Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily, expressed in several cells and tissues including T lymphocytes, NK cells and …
Structures of mouse and human GITR–GITRL complexes reveal ...
Mar 2, 2021 · Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and GITR ligand (GITRL) are members of the tumor necrosis superfamily that play a role in …
What are GITRL modulators and how do they work?
Jun 25, 2024 · GITRL, short for Glucocorticoid-Induced TNFR-Related Ligand, is a member of the tumor necrosis factor (TNF) superfamily. It binds to its receptor, GITR (Glucocorticoid-Induced …
GITR: a modulator of immune response and inflammation
Glucocorticoid-Induced TNFR-Related (GITR) protein belongs to Tumor Necrosis Factor Receptor Superfamily (TNFRSF) and stimulates both the acquired and innate immunity.