While many cases of small vessel disease are linked to common risk factors, specific genetic mutations can directly cause hereditary forms. One of the most recognized genetic forms is Cerebral …

While the role of vascular risk factors in CSVD is well known and its management is pivotal in mitigating the clinical effects, recent research has identified novel genetic factors involved in CSVD.

Apr 22, 2025 · Genetic small vessel diseases encompass a group of inherited disorders that primarily affect the small blood vessels in the brain.

Jan 5, 2022 · Fifty-two independent genetic loci have been associated with cerebral small vessel disease (cSVD) at the genome-wide significance level, including loci associated with cSVD-related …

Apr 10, 2024 · For both pathologies a strong genetic component has been identified. The genetic component of CSVD can be divided into polygenic or sporadic diseases and monogenic or familial …

Monogenic CSVDs are responsible for 1%–5% of all strokes and for several other disturbances. Despite many genes being involved, the phenotypes of monogenic CSVD partly overlap.

Aug 6, 2025 · Despite significant progress through large-scale genome-wide association studies (GWAS) for cSVD and stroke, the genetic architecture underlying these conditions remains poorly …

Apr 24, 2023 · While the role of vascular risk factors in CSVD is well known and its management is pivotal in mitigating the clinical effects, recent research has identified novel genetic factors involved …

May 28, 2025 · Results: In the primary analysis, no significant causal associations were found between genetic markers for CSVD phenotypes and poor functional outcomes (modified Rankin Scale ≥ 3) …

Microangiopathy (also known as microvascular disease, small vessel disease (SVD) or microvascular dysfunction) is a disease of the microvessels, small blood vessels in the microcirculation. [1] It can …