CD28 serves as a receptor for CD80 (B7.1) and CD86 (B7.2), proteins found on antigen-presenting cells (APCs). CD28 is the only B7 receptor consistently expressed on naive T cells. In the absence of …

Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell receptor (TCR) ligation for naive T cell activation. Here we discuss the expression, structure, and biochemistry of …

Nov 13, 2025 · Complete information for CD28 gene (Protein Coding), CD28 Molecule, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene …

Jul 25, 2024 · In this Review, we explore recent insights into the molecular functions and regulation of CD28.

Figure 1. The CD28 receptor system. CD28 and CTLA-4 are stimulated by CD80 and CD86 ligands on activated APCs. Signals from CD28 are required for T cell activation and cytokine secretion, while …

We discuss the function of CD28 and its ligands in both effector and regulatory T cells. CD28 is critical for regulatory T cell survival and the maintenance of immune homeostasis. We outline the roles that …

Nov 26, 2025 · The CD28 receptor on the T cell surface provides the co-stimulatory Signal 2, acting as the necessary “go” signal for activation. CD28 is constitutively expressed on most T cells.

Dec 15, 2023 · The receptors of the CD28 family interact with the B7 family of ligands. The cooperation between these molecules is essential for controlling the course of the adaptive response, but it also …

CD28 (Cluster of Differentiation 28) is a protein expressed on T cells that acts as a co-stimulator, essential for T cell activation and survival. When CD28 is stimulated alongside the T-cell receptor …

CD28 family receptors are a group of regulatory cell surface receptors expressed on immune cells. The CD28 family in turn is a subgroup of the immunoglobulin superfamily.