Mexican Economy Minister Marcelo Ebrard said on Wednesday that a 25% across-the-board tariff proposed by U.S. President-elect Donald Trump would lead to the loss of 400,000 jobs in the United States,

Donald Trump’s threat to impose tariffs on goods from Canada and Mexico could upend current U.S.-Mexico cooperation on immigration.

The president-elect’s opening salvo in trade and border talks with the United States’ neighbors is casting a harsh light on the North American alliance.