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Cancer Research7d
Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity Available to Purchase - American Association for Cancer Research
We identified mutation-harboring precancerous cells that emerge via oligodendrocyte progenitor cell fate specification and contribute to the evolution of GBM with intratumoral molecular heterogeneity.
Cancer Research8d
Artificial Intelligence–Driven Cancer Diagnostics: Enhancing Radiology and Pathology through Reproducibility, Explainability, and Multimodality | Cancer Research | American ...
Abstract. The integration of artificial intelligence (AI) in cancer research has significantly advanced radiology, pathology, and multimodal approaches, offering unprecedented capabilities in image ...
Cancer Research8d
Paving a Path to Clinical Impact with Radiomics: Enabling Reproducibility and Reach Available to Purchase - American Association for Cancer Research
Abstract. Radiomics, the extraction of quantitative data from images, holds promise for noninvasively characterizing tumor phenotypes. Tools like LIFEx have improved the accessibility, transparency, ...
Cancer Research8d
Leveraging Whole-Exome Sequencing and Mutational Signatures to Detect Homologous Recombination Deficiency in Cancer Available to Purchase - American Association for Cancer Research
Homologous recombination is a high-fidelity DNA repair mechanism essential for maintaining genome stability. Impairment of this pathway, often due to BRCA1 or BRCA2 inactivation, leads to homologous ...
Cancer Research8d
T-Cell Engager Gets Accelerated Approval Free - American Association for Cancer Research
The FDA today granted accelerated approval to linvoseltamab (Lynozyfic, Regeneron) for adults with relapsed or refractory multiple myeloma who have already received at least four therapeutic regimens.
Cancer Research8d
Targeting Cancer-Associated Glycosylation for Adoptive T-cell Therapy ...
Chimeric antigen receptor (CAR) T-cell therapy has improved outcomes for patients with chemotherapy-resistant B-cell malignancies. However, CAR T-cell treatment of patients with solid cancers has been ...
Cancer Research8d
Multitask Deep Learning Based on Longitudinal CT Images Facilitates Prediction of Lymph Node Metastasis and Survival in Chemotherapy-Treated Gastric Cancer | Cancer Research ...
Accurate preoperative assessment of lymph node metastasis (LNM) and overall survival (OS) status is essential for patients with locally advanced gastric cancer receiving neoadjuvant chemotherapy, ...
Cancer Research8d
Histotripsy-Focused Ultrasound Treatment Abrogates Tumor Hypoxia Responses and Stimulates Antitumor Immune Responses in Melanoma - American Association for Cancer Research
Abstract. Histotripsy-focused ultrasound treatment gives rise to systemic antitumor immune responses. We investigated whether histotripsy effects on immunosuppressive tumor hypoxia were a potential ...
Cancer Research8d
METTL3 Inhibition Restores PD-L1 Expression and CD8
The efficacy of immunotherapy targeting PD-1/PD-L1 in gastric cancer depends on PD-L1 expression levels and the infiltration of immune cells within the tumor microenvironment (TME). Although ...
Cancer Research8d
A Dendritic Cell–Like Transition of T Cells Is Associated with Spontaneous Remission of Adult T-Cell Leukemia–Lymphoma - American Association for Cancer Research
Spontaneous remission in patients with various cancers has been reported. Some patients with adult T-cell leukemia–lymphoma (ATL) have experienced spontaneous remission, although the mechanisms for ...
Cancer Research8d
Chronic Stress Stimulates Protumor Macrophage Polarization to Propel Lung Cancer Progression Available to Purchase - American Association for Cancer Research
Chronic psychologic stress is often associated with manifestations of malignant diseases. Identification of modulators regulating the interaction between stress and tumorigenesis could provide ...