Christian McCaffrey and the 49ers travel to Buffalo to take on Josh Allen and the Bills for Sunday Night Football. Live ...

Following their bye week, the Bills (9-2) will take on the San Francisco 49ers (5-6) at Highmark Stadium in Week 13. But ...

The San Francisco 49ers may again be without starting quarterback Brock Purdy for their Week 13 clash with the San Francisco ...

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air ...

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got ...

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

George Kittle will lead the San Francisco 49ers into their matchup versus the Buffalo Bills at Highmark Stadium on Sunday at ...

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

The Buffalo Bills are heading out of the their bye and are set to face the San Francisco 49ers in Week 13 on “Sunday Night ...

Buffalo Bills look to extend its six-game win streak as Josh Allen faces an unfamiliar foe in the San Francisco 49ers at ...