San Francisco 49ers star tight end George Kittle missed his second straight practice on Friday as ESPN insider Adam Schefter ...

The Niners will perhaps be without arguably their three most important offensive weapons, sidelined stars Christian McCaffrey ...

Week 3 matchup vs. Rams with key injuries to McCaffrey, Samuel, and Kittle, testing their depth in this crucial NFC West ...

The first two weeks of the NFL season delivered plenty of unexpected chaos. Many were quick to overreact to Week 1 games, leading to several upsets in Week 2. C ...

An oblique injury has kept Seattle Seahawks running back Kenneth Walker III out of the lineup. He missed their Week 2 win ...

Two NFC West teams renew their rivalry as we continue our NFL odds series with a 49ers-Rams prediction and pick.

The latest name to the list of potentially absent players for Sunday’s Week 3 game between San Francisco and L.A. is 49ers ...

Mike Fisher - as a newspaper beat writer and columnist and on radio and TV, where he is an Emmy winner - has covered the NFL ...

The San Francisco 49ers will face the Los Angeles Rams on Sunday without wide receiver Deebo Samuel and running back ...

NFL teams grapple with mounting injuries, forcing them to rely on backups and adapt strategies as the season progresses.