San Francisco 49ers star running back Christian McCaffrey suffered a PCL injury and is expected to miss six weeks, head coach ...

In eight season’s San Francisco 49ers tight end George Kittle never played in Buffalo at Highmark Stadium. Despite the loss ...

The 49ers’ goal last offseason was to strengthen their depth in pursuit of another NFC crown. That depth has been tested and ...

The San Francisco 49ers have been decimated by injuries, but their struggles this year go beyond that. The team does not look ...

The San Francisco 49ers suffered another disappointing loss on Sunday night as they took on the Buffalo Bills on the road in ...

The defense has been shockingly bad for the Cowboys this season, especially for a group that has been known for their ...

San Francisco 49ers star Christian McCaffrey is believed to have suffered a PCL injury during the Niners’ 35-10 loss to the ...

After sparking the 49ers with a handful of impressive runs, Christian McCaffrey looked like himself early in the game against ...

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

San Francisco 49ers running back Christian McCaffrey suffered an an apparent non-contact lower leg injury on Sunday Night ...