Background: Standard pharmacotherapy for patients with heart failure with reduced ejection fraction (HFrEF) comprises “quadruple therapy” with a renin–angiotensin system inhibitor, a β-blocker, a ...

Solutions are needed in Canada to meet the health care needs of the growing number of adults with complex genetic neurodevelopmental conditions who have aged out of pediatric systems into adult ...

In Canada, an estimated 5400 deaths attributable to AMR occurred in 2018.[1][1] By 2050, 40% of infections will be resistant to first-line antimicrobials.[1][1] The pan-Canadian action plan on AMR has ...

Access to health care: Emergency department use before cancer diagnosis in Ontario, Canada: a population-based study ...

The syndrome of thrombocytopenia, anasarca, reticulin fibrosis, renal dysfunction, organomegaly (TAFRO) is a rare subtype of idiopathic multicentric Castleman disease. This syndrome should be ...

Heart failure is an increasingly common and fatal disease and causes a heavy patient, health care–system, and cost burden. A cost-effectiveness study looking at different scenarios of achieving ...

Anal cancer is caused mainly by human papillomavirus (HPV), most commonly HPV-16. It occurs in 1–2 per 100 000 people in the general population, increases with older age, and is rare in those younger ...

Acute rheumatic fever should be considered in patients with recent pharyngitis and migratory polyarthritis, heart failure, new or worsened mitral regurgitation, chorea, or cutaneous findings. In ...

Correction to “Advances in the management of renal cell carcinoma” ...