ahajournals.org3d
Association of Coagulation Factor XI Level With Cardiovascular Events and Cardiac Function in Community-Dwelling Adults: From ARIC and CHS
BACKGROUND: Coagulation factor XI (FXI) inhibitors are a promising and novel class of anticoagulants, but a recent animal study found that FXI inhibition exacerbated diastolic dysfunction and heart ...
ahajournals.org3d
A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease
BACKGROUND: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart ...
ahajournals.org4d
S100A1ct: A Synthetic Peptide Derived From S100A1 Protein Improves Cardiac Performance and Survival in Preclinical Heart Failure Models
The EF-hand Ca 2+ sensor protein S100A1 has been identified as a molecular regulator and enhancer of cardiac performance. The ability of S100A1 to recognize and modulate the activity of targets such ...
ahajournals.org6d
Pulmonary Hypertension: From Therapeutic Nihilism to Multiple Therapeutic Interventions
The ability to characterize the pulmonary circulation more fully paved the way for many advances. In the 1950s, Dr David ...