The Israel-Iran conflict has escalated into its fourth day with mounting casualties, widening attacks, and no sign of diplomatic resolution.

President Trump rejected an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei, a senior U.S. official told USA TODAY.

Israel warned Tehran civilians to evacuate the city ahead of planned Israeli strikes on “the Iranian regime’s military infrastructure” on Monday—the first time in the now four-day conflict that an evacuation warning has been issued for targeted residential areas.

Since Israel began its concerted attack on Iran on Friday, calls for regime change in Iran have grown louder – from hawks in the US Congress to Israeli officials and some Iranian activists abroad.

The Washington-based group Human Rights Activists reported a far higher death toll in Iran from Israeli strikes, saying the attacks have killed at least 406 people and wounded another 654. In recent crises, Iran routinely has undercounted casualties, including in the 2022 mass demonstrations over mandatory hijab laws after the death of Mahsa Amini.

Israel warns "Tehran will burn" if Iran continues firing missiles, while state media say 60 people have been killed in a strike on Iran's capital.

The war between Israel and Iran is in its fourth day, with Israel striking at military sites and Iran's nuclear program and Iran firing missiles in retaliation