Researchers from the University of Sydney have developed a system that mimics natural selection inside living mammalian cells ...

Overall, the team’s findings support a model whereby selective pressure from vertebrate hosts maintains the alphavirus nsP3 opal codon because this codon keeps nsP4 levels in a Goldilocks zone: enough ...

Salmonid alphavirus (SAV) represents a significant pathogen in aquaculture, causing pancreas disease (PD) that imposes substantial economic and welfare challenges worldwide.

Arthritogenic alphaviruses, including chikungunya (CHIKV) and Mayaro virus (MAYV), cause disease characterized by fever, rash, and incapacitating joint pain. Alphavirus arthritis is associated with ...

Heterologous prime-boost immunization strategies in general establish higher frequencies of antigen-specific T lymphocytes than homologous prime-boost protocols or single immunizations. We developed ...

Neste trabalho, analisa-se o risco de emergência dos alphavirus Mayaro, da encefalite eqüina venezuelana, da encefalite eqüina do leste e Chikungunya, dos flavivirus, da febre amarela, Rocio, da ...

Arboviral encephalitis is a potentially devastating human disease with no approved therapies that target virus replication. We previously discovered a novel class of thieno[3,2-b]pyrrole-based ...

With this structural background, the alphaviruses represent an intriguing new fusion principle, differing in many aspects from the established influenza model. This mechanism is now on its way to be ...

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70. Sun B, Skjaeveland I, Svingerud T, Zou J, Jorgensen J, and Robertsen B. Antiviral activity of salmonid gamma interferon against infectious pancreatic necrosis virus and salmonid alphavirus and its ...

RNA-targeting compounds or small interfering RNAs (siRNAs) offer a potent means to control viral infections. An essential prerequisite for their design depends on identifying conserved and functional ...