The use of a PRG allows us to monitor Cre recombinase-mediated recombination noninvasively and repeatedly in the same animal. In addition, this approach may also allow us to track the in vivo ...

A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." In this new ...

To test whether AdRP2105a could act as a helper virus for amplification of hdAd, we performed an experiment in which we compared hdAd amplification using the standard Cre/lox system (Figure 3b), ...

Cre-loxP, a powerful tool for preclinical cancer research, possesses intrinsic pitfalls that can alter result accuracy, according to an editorial paper in Oncoscience. Cancer and other diseases could ...

To discover the function of a gene researchers turn it off and observe the consequences. Often genes have multiple functions that differ depending on a tissue and age. Some genes are essential to ...

We have created a stable transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled T cell acute lymphoblastic leukemia (T-ALL), allowing visualization of the onset and spread of this disease.

Scientists of the National Center for Cardiovascular Research (CNIC) led by Rui Benedito have developed a new genetic tool (iSuRe-Cre) that provides certainty in Cre-inducible genetic modifications, a ...

We spoke to Stefan Momma, Group Leader, University Hospital Frankfurt, at Extracellular Vesicles 2016. with the Breaking Science News daily newsletter ...

(Nanowerk News) A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing ...

A team of scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Rui Benedito has generated a novel genetic tool, called iSuRe-HadCre, that enables the induction of ...