ALZFORUM3d
What’s Inside Those Mysterious Biondi Bodies? Hello, TMEM106B!
Behold the Body. Electron microgram of a Biondi body shows a dense core surrounded by filaments that bind gold-labeled secondary antibody to TMEM239 (black dots). [Courtesy of Ghetti et al., 2024.] ...
ALZFORUM4d
In Familial Alzheimer’s, β-Synuclein Rises in Blood a Decade Before Onset
Alzheimer’s disease is a long, slow neurodegenerative calamity, and scientists are still hunting for blood biomarkers that reflect all its specific stages. At the Clinical Trials on Alzheimer’s ...
ALZFORUM8d
Some Alzheimer’s Blood Tests Are Racing Toward IVD Certification
Yes, blood tests for Alzheimer’s disease are ready for prime time. So pronounced Suzanne Schindler, Washington University, St. Louis, in a keynote presentation at CTAD 2024 last month in Madrid. In ...
ALZFORUM8d
Just as Sharp: MRI Scans at Triple the Speed
Rosa-Grilo incorporated Wave-CAIPI into the diagnostic scanning protocol used at UCL’s memory clinic. It comprises four sequences: T1-weighted 3D, T2-weighted 2D, T2-weighted 3D, and 3D FLAIR imaging.
ALZFORUM8d
Beyond Antibodies: From CTAD, New Attempts at Outflanking Alzheimer’s
Mivelsiran docks APP products in early AD. Phase 2 trial asks: Can it treat CAA? LX1001 gene therapy boosts CSF ApoE2, stabilizes AD biomarkers. Intranasal insulin quells systemic inflammation. These ...
ALZFORUM10d
Biomarkers Suggest Black and Hispanic People Less Likely to Have Amyloid
Despite higher rates of clinically diagnosed dementia among people from non-white racial and ethnic groups, historically they have been underrepresented in AD clinical trials. Efforts are underway to ...