Expert Rev Clin Pharmacol. 2010;3(3):321-329. Despite a propensity to block hERG channel function, as determined by electrophysiology, for a limited number of compounds no cardiac arrhythmias have ...
The hERG channel is a voltage-gated potassium (Kv) channel that is expressed in the heart. In contrast to other Kv channels, the gating properties of hERG channels are unique and poorly understood.
Electrical impedance tomography–extracellular voltage activation technique simplifies drug screening
The EIT–EVA PCB sensor setup used to evaluate the effects of drugs on hERG channels. The sensor measures changes in extracellular resistance as voltage-gated hERG channels are activated and inhibited, ...
When developing new drugs, understanding their effects on ion channels in the body, such as the human ether-a-go-go-related gene (hERG) ion channel found in neurons and heart muscle cells, is critical ...
CAMBRIDGE, England--(BUSINESS WIRE)--Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced it has received notification from ...
Repolarization abbreviation with the antiarrhythmic drug mexiletine has been found to normalize the QTc interval and reduce the rate of events in long QT syndrome type 3 (LQT3), but it is only ...
CiPA Initiative Aims to Better Detect Drug-Induced Cardiac Arrhythmias With cardiovascular side effects an ever-pressing concern in drug safety, interest is growing in ion channel assays and in silico ...
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