Using ribosome engineering (RE), researchers from Shinshu University introduced mutations affecting the protein synthesis ...

A change in the DNA sequence of a codon may not change the corresponding amino acid residue in the encoded protein because each residue can be encoded by several codons. This is called the Wobble ...

Researchers have developed the first mouse model for a mitochondrial tRNALeu mutation, showing that the associated metabolic disorder results from faulty RNA processing. Studying the role of ...

Although synonymous (or “silent”) variants have no effect on amino acid sequence, some synonymous variants influence fitness and susceptibility to disease. Mechanisms include interference with ...

A research team led by Prof. XU Zhiheng from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has identified Tapt1, together with its partner Suco, as important ...

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

Using ribosome engineering (RE), researchers from Shinshu University introduced mutations affecting the protein synthesis ...