The hippocampus serves as the primary learning and memory center of the brain, but this is not where our memories are held. Rather, memory traces or engrams are represented by the connections between ...

LA JOLLA, CA – Using cutting-edge genetic tools, 3D electron microscopy, and artificial intelligence, Scripps Research scientists and colleagues have uncovered key structural hallmarks of long-term ...

Dynamic mechanisms of engram maturation. During the allocation, engram allocation is primarily governed by enhancements in intrinsic neuronal excitability, driven primarily by increased ...

The brain stores memories through a neuronal ensemble, termed engram cells. A unique system was established to transfer neuronal population activity into light with discrimination between engram and ...

Scientists from the University of Buffalo, Imperial College London, Massachusetts Institute of Technology, and elsewhere have published new research that demonstrates how brain cells get better at ...

Skoltech scientists have devised a mathematical model of memory. By analyzing its new model, the team came to surprising conclusions that could prove useful for robot design, artificial intelligence, ...

Though scientist Richard Semon introduced the concept of the "engram" 115 years ago to posit a neural basis for memory, direct evidence for engrams has only begun to accumulate recently as ...

Optogenetics and advanced imaging have helped neuroscientists understand how memories form and made it possible to manipulate them. There are 86 billion neurons in the human brain, each with thousands ...

As far back as Plato and Aristotle, people believed that our memories had to be physical somethings that were stored somewhere in the brain. But only in modern times have we learned much about what ...

Sheena Josselyn discussed how she uses optogenetic tools to bias, express, and erase memories in mice. Shortly before we trained mice to associate a context with an aversive foot shock, we activated ...