Recent years have seen major advances in understanding the structure-function relationships of G protein-coupled receptors (GPCRs). This large superfamily of transmembrane receptors comprises over 800 ...
β2 adrenergic receptor (β2AR) agonism improves muscle glucose uptake and whole-body glucose homeostasis in rodents, an effect which is dependent on GPCR kinase 2 (GRK2). However, β2AR agonism has not ...
Most protein-targeting drugs are prizes that drug developers have unearthed from G protein–coupled receptor (GPCR) interactomes. So, when GPCR-targeting drugs become harder to find, one might liken ...
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