Duchenne muscular dystrophy (DMD) is a genetic disease characterized by progressive degeneration of the skeletal muscle leading to permanent weakness and disability. Most patients die during the third ...
Pulmonary fibrosis (PF) refers to a group of interstitial lung diseases characterized by fibrotic remodeling, triggered by known environmental, occupational, or therapeutic exposures such as radiation ...
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...
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