Scientists have uncovered a brain mechanism that may explain why chronic pain leads to depression in some people but not ...

“Understanding the mechanisms that underly the antidepressant effects of physical activity in depression could also inform our understanding of the mechanisms causing depression and the development of ...

Treatment-resistant depression affects a large proportion of people with major depressive disorder, and while ketamine offers ...

Researchers identify the hippocampus and microglia as the "tipping point" that determines if chronic pain leads to depression ...

Read more about the biological and psychosocial factors implicated in the relationship between PCOS and depression.

A newly discovered human gene mutation appears to contribute both to unusual sleep patterns and to heightened rates of seasonal depression, according to new research from UC San Francisco. Although ...

Clinical depression is often linked to aches and pains, including back pain. Having chronic back pain is also associated with worsening depression symptoms in some people. Research indicates there’s a ...

As someone who has been involved in psychiatric drug development and clinical strategy for more than two decades, I believe ...

Why does ketamine wear off so fast? New research identifies the NOX-1 enzyme as a key target to prolong ketamine’s antidepressant effects for treatment-resistant depression.

Depression affects millions of people worldwide, manifesting through various emotional, cognitive, and physical symptoms. While everyone experiences occasional sadness, clinical depression involves ...