The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

The contraction of smooth muscle is an essential process underpinning diverse physiological functions ranging from gastrointestinal motility to vascular regulation. At its core, smooth muscle ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

IT is well established that an increase in the intracellular concentration of ionized calcium after excitation in the membrane is the key factor for initiation of contraction of various types of ...

New research reveals that type 2 diabetes doesn’t just raise the risk of heart disease, it physically reshapes the heart ...

The ability to modify the intracellular concentrations of divalent calcium ions is vital to normal cell functioning. In the cells of the cardiac muscle, calcium ions play a crucial role in coupling ...

Uncover how a consistent dairy routine rebuilds mineral density and acts as a biological shield against the silent threat of ...

Calcium is one of the most vital minerals for the human body, playing an essential role in maintaining strong bones, healthy teeth, and numerous bodily functions. While many people associate calcium ...

Calcium is the most abundant mineral in the body, and it’s essential for performing a wide variety of functions from building strong bones and teeth to boosting muscle function and even secreting ...

The top row of photos show a microscopic view of healthy muscle fibers stained to reveal a variety of irregularities, while the bottom row shows the same but for muscle fibers afflicted by the disease ...