Axonal degeneration and neuroinflammation are increasingly recognised as pivotal processes in the pathogenesis of neurodegenerative diseases. Axonal degeneration refers to the progressive ...

Neurotrophin signalling orchestrates a myriad of cellular events essential for the development, survival, and functional maintenance of sympathetic neurons. Neurotrophins such as nerve growth factor ...

Schematic representation of axonal transport vesicles (blue) carrying presynaptic proteins (SV and AZ proteins). Kinesin motor proteins (KIF1A) attach these vesicles and carry them along the axons to ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

RNA granules, sites for the storage, transport, and regulation of RNA molecules within cells, are transported along axons and then translated locally, far from the cell body. Recent studies suggest ...

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

Researchers found that inhibiting GSK-3 led to less defects in the axonal transport process and less neuronal cell death, while inhibiting ERK1 led to more transport problems and more cell death. A ...

Axons connect neurons across great distances in the nervous system, and this distance is a fundamental vulnerability for neurons. Maintenance of functional connectivity requires robust mechanisms for ...

Indiana University researchers in the College of Arts and Sciences in Bloomington have identified a missing link that can help protect the brain from aging. Carnegie Mellon University's Jessica Zhang ...

This movie shows axonal organelle transport in nerve fibers isolated from transgenic mice that express a fluorescent protein in their neuronal mitochondria. The top and bottom are controls (normal, ...