Tauopathies are classified by which tau isoform forms fibrils—those with three microtubule-binding domain repeats (3R), those with four (4R), or those with both. What drives one isoform to aggregate ...
An imbalance of tau isoforms containing either three or four microtubule-binding repeats causes frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) in families with intronic ...
Structural characteristics of the self-assembled nr-YH peptide on graphite and molybdenite. (A to C) FM-AFM-recorded molecular resolution images of the self-assembled 3r-, 4r-, and 5r-YH peptides ...
Misfolded tau forms fibrillar “seeds” that lure properly folded tau monomers into their toxic fold. Now, using new cell lines designed to detect such molecular subterfuge, researchers led by Nobel ...
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