This week, the Packers will take on the San Francisco 49ers as 5.5-point home favorites in the Week 12 NFL odds with an over-under of 44.5, one of the three NFL games in the late afternoon window. Can Love's team beat the defending NFC champions this week in a rematch from last year's Divisional Round or will his interception issues continue to plague the Packers?

According to our projections, the best bet against the spread in the NFL among Week 12’s 13 matchups is Cardinals -1 — for more tips, including parlay possibilities, scroll down. Find an edge on the competition and take advantage of our spread picks for the NFL.

Week 12 of the NFL season features lots of divisional matchups and a few games with large spreads. Here's who could beat the spread on Sunday.