The Israeli military said an entire Tehran neighborhood should evacuate ahead of planned strikes there, as residents of Iran’s capital piled onto roads heading north to seek shelter from the fourth day of bombardment.

For years, the veteran leader has made the destruction of Iran’s nuclear program his top priority, raising the issue in speech after speech in apocalyptic terms.

Israel unleashed airstrikes across Iran for a third day Sunday and threatened even greater force as some Iranian missiles evaded Israeli air defenses to strike buildings in the heart of the country.